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Mendeley readers
Attention Score in Context
| Title |
Chemical Characterization of the Smallest S-Nitrosothiol, HSNO; Cellular Cross-talk of H2S and S-Nitrosothiols
|
|---|---|
| Published in |
Journal of the American Chemical Society, July 2012
|
| DOI | 10.1021/ja3009693 |
| Pubmed ID | |
| Authors |
Milos R. Filipovic, Jan Lj. Miljkovic, Thomas Nauser, Maksim Royzen, Katharina Klos, Tatyana Shubina, Willem H. Koppenol, Stephen J. Lippard, Ivana Ivanović-Burmazović |
| Abstract |
Dihydrogen sulfide recently emerged as a biological signaling molecule with important physiological roles and significant pharmacological potential. Chemically plausible explanations for its mechanisms of action have remained elusive, however. Here, we report that H(2)S reacts with S-nitrosothiols to form thionitrous acid (HSNO), the smallest S-nitrosothiol. These results demonstrate that, at the cellular level, HSNO can be metabolized to afford NO(+), NO, and NO(-) species, all of which have distinct physiological consequences of their own. We further show that HSNO can freely diffuse through membranes, facilitating transnitrosation of proteins such as hemoglobin. The data presented in this study explain some of the physiological effects ascribed to H(2)S, but, more broadly, introduce a new signaling molecule, HSNO, and suggest that it may play a key role in cellular redox regulation. |
Mendeley readers
The data shown below were compiled from readership statistics for 158 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 2 | 1% |
| Brazil | 2 | 1% |
| Argentina | 1 | <1% |
| Japan | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 151 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 43 | 27% |
| Researcher | 30 | 19% |
| Professor > Associate Professor | 14 | 9% |
| Student > Doctoral Student | 10 | 6% |
| Student > Bachelor | 10 | 6% |
| Other | 28 | 18% |
| Unknown | 23 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 73 | 46% |
| Biochemistry, Genetics and Molecular Biology | 20 | 13% |
| Agricultural and Biological Sciences | 18 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 4% |
| Medicine and Dentistry | 5 | 3% |
| Other | 5 | 3% |
| Unknown | 31 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 January 2022.
All research outputs
#4,116,252
of 22,851,489 outputs
Outputs from Journal of the American Chemical Society
#14,354
of 62,045 outputs
Outputs of similar age
#25,308
of 143,611 outputs
Outputs of similar age from Journal of the American Chemical Society
#169
of 536 outputs
Altmetric has tracked 22,851,489 research outputs across all sources so far. Compared to these this one has done well and is in the 81st percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 62,045 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.8. This one has done well, scoring higher than 76% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 143,611 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 82% of its contemporaries.
We're also able to compare this research output to 536 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.